Issue 48, 2007
From the journal:

Chemical Communications

Chlorodifluoromethyl phenyl sulfone: a novel non-ozone-depleting substance-based difluorocarbene reagent for O- and N-difluoromethylations†‡

Ji Zheng,a   Ya Li,a   Laijun Zhang,a   Jinbo Hu,*a   Gerrit Joost Meuzelaarb  and  Hans-Jürgen Federselb  

* Corresponding authors

a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, China
E-mail: jinbohu@mail.sioc.ac.cn
Fax: +86 21-64166128

b Global Process R&D, Södertälje site, AstraZeneca, S-151 85 Södertälje, Sweden

Abstract

Chlorodifluoromethyl phenyl sulfone, a previously unknown compound that can be readily prepared from non-ODS-based precursors, was found to act as a robust difluorocarbene reagent for O- and N-difluoromethylations.

Graphical abstract: Chlorodifluoromethyl phenyl sulfone: a novel non-ozone-depleting substance-based difluorocarbene reagent for O- and N-difluoromethylations

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Article information

DOI
https://doi.org/10.1039/B713156A
Article type
Communication
Submitted
28 Aug 2007
Accepted
28 Sep 2007
First published
16 Oct 2007

Chem. Commun., 2007, 5149-5151

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Chlorodifluoromethyl phenyl sulfone: a novel non-ozone-depleting substance-based difluorocarbene reagent for O- and N-difluoromethylations

J. Zheng, Y. Li, L. Zhang, J. Hu, G. J. Meuzelaar and H. Federsel, Chem. Commun., 2007, 5149 DOI: 10.1039/B713156A

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