Issue 43, 2007

Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine

Abstract

Asymmetric substitution of 2-lithiopiperidines can be achieved by dynamic resolution; the organolithium is formed as a racemic mixture by proton abstraction (or tin–lithium exchange) and is resolved in the presence of a chiral ligand.

Graphical abstract: Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine

Supplementary files

Article information

Article type
Communication
Submitted
03 Jul 2007
Accepted
04 Sep 2007
First published
12 Sep 2007

Chem. Commun., 2007, 4534-4536

Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine

I. Coldham, J. J. Patel, S. Raimbault and D. T. E. Whittaker, Chem. Commun., 2007, 4534 DOI: 10.1039/B710066C

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