Issue 43, 2007
From the journal:

Chemical Communications

Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine†

Iain Coldham,*a   Jignesh J. Patel,a   Sophie Raimbaulta  and  David T. E. Whittakerb  

* Corresponding authors

a Department of Chemistry, University of Sheffield, Sheffield, UK
E-mail: i.coldham@sheffield.ac.uk
Fax: (+44) 114 222 9346
Tel: (+44) 114 222 9428

b AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK

Abstract

Asymmetric substitution of 2-lithiopiperidines can be achieved by dynamic resolution; the organolithium is formed as a racemic mixture by proton abstraction (or tin–lithium exchange) and is resolved in the presence of a chiral ligand.

Graphical abstract: Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B710066C
Article type
Communication
Submitted
03 Jul 2007
Accepted
04 Sep 2007
First published
12 Sep 2007

Chem. Commun., 2007, 4534-4536

Permissions

Request permissions

Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine

I. Coldham, J. J. Patel, S. Raimbault and D. T. E. Whittaker, Chem. Commun., 2007, 4534 DOI: 10.1039/B710066C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements