Issue 42, 2007
From the journal:

Chemical Communications

pH-Controllable drug release using hydrogel encapsulated mesoporous silica†

S.-W. Song,a   K. Hidajata  and  S. Kawi*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 119260
E-mail: chekawis@nus.edu.sg
Fax: +65-67791936
Tel: +65-65166312

Abstract

Amine-functionalized mesoporous SBA-15 silica loaded with bovine serum albumin (BSA) has been successfully encapsulated with a thin layer coating of poly(acrylic acid) PAA, with the entrapped BSA being released from the PAA-encapsulated SBA-15 at the higher pH value of 7.4 rather than at the lower pH value of 1.2. This novel drug delivery system has a potential application in the release of protein drug to the site of higher pH value, such as small intestine or colon.

Graphical abstract: pH-Controllable drug release using hydrogel encapsulated mesoporous silica

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Article information

DOI
https://doi.org/10.1039/B707626F
Article type
Communication
Submitted
21 May 2007
Accepted
20 Jul 2007
First published
20 Aug 2007

Chem. Commun., 2007, 4396-4398

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pH-Controllable drug release using hydrogel encapsulated mesoporous silica

S.-W. Song, K. Hidajat and S. Kawi, Chem. Commun., 2007, 4396 DOI: 10.1039/B707626F

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