Issue 9, 2007
From the journal:

Chemical Communications

Dry and wet prolines for asymmetric organic solvent-free aldehyde–aldehyde and aldehyde–ketone aldol reactions†

Yujiro Hayashi,*a   Seiji Aratake,a   Takahiko Itoh,a   Tsubasa Okano,a   Tatsunobu Sumiyaa  and  Mitsuru Shojia  

* Corresponding authors

a Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo, Japan
E-mail: hayashi@ci.kagu.tus.ac.jp
Fax: +81-(0)3-5261-4631
Tel: +81-(0)3-5228-8318

Abstract

Dry and wet prolines were found to catalyze the direct aldol reactions of aldehyde–aldehyde and aldehyde–ketone, respectively, to afford aldols with excellent diastereo- and enantioselectivities, and an organic solvent-free reaction was realized in some cases.

Graphical abstract: Dry and wet prolines for asymmetric organic solvent-free aldehyde–aldehyde and aldehyde–ketone aldol reactions

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Article information

DOI
https://doi.org/10.1039/B613262F
Article type
Communication
Submitted
12 Sep 2006
Accepted
27 Nov 2006
First published
08 Dec 2006

Chem. Commun., 2007, 957-959

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Dry and wet prolines for asymmetric organic solvent-free aldehyde–aldehyde and aldehyde–ketone aldol reactions

Y. Hayashi, S. Aratake, T. Itoh, T. Okano, T. Sumiya and M. Shoji, Chem. Commun., 2007, 957 DOI: 10.1039/B613262F

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