Issue 9, 2007

Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics

Abstract

Replacement of the thiazolium ring of thiamine pyrophosphate with a triazole gives extremely potent inhibitors of pyruvate decarboxylase from Z. mobilis, with KI values down to 20 pM; this system was used to explore pyrophosphate mimics and several effective analogues were discovered.

Graphical abstract: Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics

Supplementary files

Article information

Article type
Communication
Submitted
01 Nov 2006
Accepted
27 Nov 2006
First published
08 Dec 2006

Chem. Commun., 2007, 960-962

Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics

K. M. Erixon, C. L. Dabalos and F. J. Leeper, Chem. Commun., 2007, 960 DOI: 10.1039/B615861G

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