Jump to main content
Jump to site search

Issue 39, 2007
Previous Article Next Article

Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis

Author affiliations

Abstract

Isolation and sequencing of a PKS gene isolated from xenovulene-producing cultures of Acremonium strictum indicated the presence of NT-, KS-, AT-, PT-, C-MeT- and R-domains; heterologous expression in Aspergillus oryzae resulted in the production of 3-methylorcinaldehyde, demonstrating the role of the terminal reductase domain in product release.

Graphical abstract: Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Jun 2007, accepted on 28 Jun 2007 and first published on 25 Jul 2007


Article type: Communication
DOI: 10.1039/B708614H
Chem. Commun., 2007, 4053-4055

  •   Request permissions

    Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis

    A. M. Bailey, R. J. Cox, K. Harley, C. M. Lazarus, T. J. Simpson and E. Skellam, Chem. Commun., 2007, 4053
    DOI: 10.1039/B708614H

Search articles by author

Spotlight

Advertisements