Jump to main content
Jump to site search

Issue 5, 2006
Previous Article Next Article

Heterovalent selectivity and the combinatorial advantage

Author affiliations


Libraries of monovalent compounds can be reacted with each other to give libraries of bivalent ones. If those reactions are efficient, and if the products do not need to be purified, large numbers of bivalent compounds can be produced rapidly, and one might say there is a “combinatorial advantage” to doing so. However, selective formation of heterobivalent products must be possible otherwise statistical mixtures will form. This tutorial review describes methods that will give heterobivalent compounds almost exclusively. Although there are relatively few methods that will give that desired selectivity, such methods are becoming increasingly important as the potential applications of bi- and multivalent compounds emerge.

Graphical abstract: Heterovalent selectivity and the combinatorial advantage

Back to tab navigation

Publication details

The article was received on 24 Nov 2005 and first published on 21 Mar 2006

Article type: Tutorial Review
DOI: 10.1039/B516721N
Chem. Soc. Rev., 2006,35, 416-423

  •   Request permissions

    Heterovalent selectivity and the combinatorial advantage

    S. J. Reyes and K. Burgess, Chem. Soc. Rev., 2006, 35, 416
    DOI: 10.1039/B516721N

Search articles by author