Issue 38, 2006
From the journal:

Chemical Communications

Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis†

Anna E. Stanley,a   Laura J. Walton,a   Malek Kourdi Zerikly,a   Christophe Correa  and  Gregory L. Challis*a  

* Corresponding authors

a Department of Chemistry, University of Warwick, Coventry, UK
E-mail: g.l.challis@warwick.ac.uk
Fax: +44 (0)24 7652 4112
Tel: +44 (0)24 7657 4024

Abstract

The biosynthetic pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor, has been elucidated using a combination of gene replacements and feeding experiments with chemically synthesised MBC and a synthetic analogue of a pathway intermediate.

Graphical abstract: Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis

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Article information

DOI
https://doi.org/10.1039/B609556A
Article type
Communication
Submitted
06 Jul 2006
Accepted
29 Aug 2006
First published
11 Sep 2006

Chem. Commun., 2006, 3981-3983

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Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis

A. E. Stanley, L. J. Walton, M. Kourdi Zerikly, C. Corre and G. L. Challis, Chem. Commun., 2006, 3981 DOI: 10.1039/B609556A

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