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Issue 4, 2006
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The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion

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Abstract

The spore photoproduct lyase is a Fe–S/AdoMet DNA repair enzyme, which directly repairs spore lesions, induced by UV irradiation of spores, using an unknown radical mechanism. The air sensitive radical SAM enzyme was for the first time challenged with synthetically pure substrates. It was found that the enzyme recognizes a synthetic 5S-configured spore lesion without the central phosphodiester bond. The 5R-configured lesion is in contrast to current belief not a substrate.

Graphical abstract: The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion

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Article information


Submitted
06 Oct 2005
Accepted
10 Nov 2005
First published
09 Dec 2005

Chem. Commun., 2006, 445-447
Article type
Communication

The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion

M. G. Friedel, O. Berteau, J. C. Pieck, M. Atta, S. Ollagnier-de-Choudens, M. Fontecave and T. Carell, Chem. Commun., 2006, 445
DOI: 10.1039/B514103F

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