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Issue 8, 2006
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Solid-phase synthesis of CD40L mimetics

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Abstract

The C3-symmetric molecule 1 has been previously shown to mimic CD40 ligand (CD40L) homotrimers and to display effector functions. This molecule consists of a cyclic hexapeptide core containing the repetition of the D-Ala-L-Lys motif. The side chains of the lysine residues have been modified by appending the CD40L-derived sequence 143Lys-Gly-Tyr-Tyr146via a 6-aminohexanoic acid residue as a spacer. The present report describes a general solid-phase synthesis approach to 1 and related trimeric architectures. In addition, their CD40 binding properties as well as their effector functions have been evaluated.

Graphical abstract: Solid-phase synthesis of CD40L mimetics

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Article information


Submitted
31 Jan 2006
Accepted
28 Feb 2006
First published
10 Mar 2006

Org. Biomol. Chem., 2006,4, 1461-1463
Article type
Communication

Solid-phase synthesis of CD40L mimetics

A. Bianco, S. Fournel, S. Wieckowski, J. Hoebeke and G. Guichard, Org. Biomol. Chem., 2006, 4, 1461
DOI: 10.1039/B601528J

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