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Issue 10, 2006
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Combinatorial receptor finding—large and random vs. small and focused libraries

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Abstract

Whereas in the classical combinatorial approach mainly large but completely random libraries are used, nowadays also the use of small but designed libraries is coming into focus. We discuss the pros and cons of these two different approaches, using examples from literature work and our own studies showing how combinatorial libraries are applied in supramolecular chemistry e.g. to identify artificial receptors for peptide binding in aqueous solvent.

Graphical abstract: Combinatorial receptor finding—large and random vs. small and focused libraries

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Article information


Submitted
18 Apr 2006
Accepted
10 Jul 2006
First published
23 Aug 2006

New J. Chem., 2006,30, 1377-1385
Article type
Perspective

Combinatorial receptor finding—large and random vs. small and focused libraries

C. Schmuck and P. Wich, New J. Chem., 2006, 30, 1377
DOI: 10.1039/B605731B

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