Issue 16, 2005
From the journal:

Organic & Biomolecular Chemistry

Two-stage enzyme mediated drug release from LMWG hydrogels

Kjeld J. C. van Bommel,*a   Marc C. A. Stuart,b   Ben L. Feringab  and  Jan van Esch*b  

* Corresponding authors

a Biomade Technology Foundation, Nijenborgh 4, Groningen, The Netherlands
E-mail: van.bommel@biomade.nl
Fax: +31 (0)50 3634429
Tel: +31 (0)50 3634599

b Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, Groningen, The Netherlands
E-mail: J.van.Esch@rug.nl
Fax: +31 (0)50 3634296
Tel: +31 (0)50 3634428

Abstract

An enzymatically cleavable low molecular weight gelator–(model) drug conjugate system can be employed to effect a two-step enzyme mediated drug release, demonstrating the potential of LMWG systems for the development of drug delivery devices.

Graphical abstract: Two-stage enzyme mediated drug release from LMWG hydrogels

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Article information

DOI
https://doi.org/10.1039/B507157G
Article type
Communication
Submitted
23 May 2005
Accepted
17 Jun 2005
First published
08 Jul 2005

Org. Biomol. Chem., 2005,3, 2917-2920

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Two-stage enzyme mediated drug release from LMWG hydrogels

K. J. C. van Bommel, M. C. A. Stuart, B. L. Feringa and J. van Esch, Org. Biomol. Chem., 2005, 3, 2917 DOI: 10.1039/B507157G

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