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Issue 3, 2005
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5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex

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Abstract

NMR studies, UV-monitored melting experiments, and ab initio calculations show that 5-hydroxyuracil, produced by the oxidative de-amination of cytosines by reactive oxygen species, can form stable base-pairs with dA, dG, dC and dT residues in a DNA duplex, providing a basis for the in-vivo incorporation of 5-hydroxyuracil during DNA replication.

Graphical abstract: 5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex

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Article information


Submitted
21 Sep 2004
Accepted
12 Oct 2004
First published
30 Nov 2004

Chem. Commun., 2005, 400-402
Article type
Communication

5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex

V. Thiviyanathan, A. Somasunderam, D. E. Volk and D. G. Gorenstein, Chem. Commun., 2005, 400
DOI: 10.1039/B414474K

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