Issue 21, 2004
From the journal:

Organic & Biomolecular Chemistry

EPR and affinity studies of mannose–TEMPO functionalized PAMAM dendrimers†

Lynn E. Samuelson,a   Karl B. Sebby,a   Eric D. Walter,a   David J. Singela  and  Mary J. Cloninger*a  

* Corresponding authors

a Department of Chemistry and Biochemistry and Center for Bioinspired Nanomaterials, Montana State University, 108 Gaines Hall, Bozeman, MT, USA
E-mail: mcloninger@chemistry.montana.edu
Fax: 406 994 5407
Tel: 406 994 3051

Abstract

Mannose–TEMPO functionalized G(4)-PAMAM dendrimers with increasing mannose loadings have been synthesized and characterized by MALDI-TOF MS and EPR spectroscopy. Analysis of linebroadening effects in the EPR spectra of these dendrimers allowed us to determine the relative presentation of mannose and TEMPO on the dendrimer surface. Hemagglutination assays and affinity chromatography/EPR experiments to assess the activity of the mannose–TEMPO dendrimers with Concanavalin A are presented.

Graphical abstract: EPR and affinity studies of mannose–TEMPO functionalized PAMAM dendrimers

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Article information

DOI
https://doi.org/10.1039/B411643G
Article type
Paper
Submitted
03 Aug 2004
Accepted
06 Sep 2004
First published
30 Sep 2004

Org. Biomol. Chem., 2004,2, 3075-3079

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EPR and affinity studies of mannose–TEMPO functionalized PAMAM dendrimers

L. E. Samuelson, K. B. Sebby, E. D. Walter, D. J. Singel and M. J. Cloninger, Org. Biomol. Chem., 2004, 2, 3075 DOI: 10.1039/B411643G

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