Issue 21, 2004
From the journal:

Chemical Communications

BINOL catalyzed enantioselective addition of titanium phenylacetylide to aromatic ketones

Pier Giorgio Cozzi*a  and  Silvia Alesia  

* Corresponding authors

a Dipartimento di Chimica “G. Ciamician”, Via Selmi 2, Bologna, Italy
E-mail: piergiorgio.cozzi@unibo.it
Fax: +39 0512099456
Tel: +39 0512099511

Abstract

An enantioselective addition of titanium phenylacetylide to ketones, promoted by BINOL, is described; this new enantioselective protocol gives high enantiomeric excess (up to 90% ee) with aromatic ketones using a simple procedure without pyrophoric or expensive reagents.

Graphical abstract: BINOL catalyzed enantioselective addition of titanium phenylacetylide to aromatic ketones

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Article information

DOI
https://doi.org/10.1039/B408654F
Article type
Communication
Submitted
09 Jun 2004
Accepted
18 Aug 2004
First published
21 Sep 2004

Chem. Commun., 2004, 2448-2449

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BINOL catalyzed enantioselective addition of titanium phenylacetylide to aromatic ketones

P. G. Cozzi and S. Alesi, Chem. Commun., 2004, 2448 DOI: 10.1039/B408654F

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