A mild and efficient procedure for α-bromination of ketones using N-bromosuccinimide catalysed by ammonium acetate
Abstract
Cyclic ketones reacted with N-bromosuccinimide (NBS) catalysed by NH4OAc in Et2O at 25 °C to give the corresponding α-brominated ketones in good yields, while acyclic ketones were efficiently brominated in CCl4 at 80 °C.