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Issue 24, 2004
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Practical and efficient enantioselective synthesis of α-amino acids in aqueous media

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Abstract

Enantiomerically pure natural and unnatural α-amino acids have been synthesized from a chiral methyleneoxazolidinone by means of a highly diastereoselective 1,4-conjugate addition of alkyl iodides in aqueous media. The zinc–copper conjugate addition reaction exhibits high chemoselectivity, with the possibility of using functionalized iodides, to afford a single diastereomer in short reaction times and with good yields.

Graphical abstract: Practical and efficient enantioselective synthesis of α-amino acids in aqueous media

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Publication details

The article was received on 25 Aug 2004, accepted on 07 Oct 2004 and first published on 09 Nov 2004


Article type: Paper
DOI: 10.1039/B413017K
Org. Biomol. Chem., 2004,2, 3584-3587

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    Practical and efficient enantioselective synthesis of α-amino acids in aqueous media

    R. M. Suárez, J. Pérez Sestelo and L. A. Sarandeses, Org. Biomol. Chem., 2004, 2, 3584
    DOI: 10.1039/B413017K

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