Issue 13, 2003
From the journal:

Organic & Biomolecular Chemistry

Synthesis of fluorophore and quencher monomers for use in Scorpion primers and nucleic acid structural probes

Catherine M. McKeen,b   Lynda J. Brown,b   Jamie T. G. Nicol,a   John M. Mellora  and  Tom Brown*a  

* Corresponding authors

a Department of Chemistry, University of Southampton, Highfield, UK
E-mail: tb2@soton.ac.uk

b Oswel Research Products Ltd., Eurogentic Group, Unit 2, Winchester Hill Commercial Park, Winchester Hill, Romsey, Hampshire, UK

Abstract

We report the syntheses of monomers to incorporate fluorescein and methyl red within the sequence and at the termini of modified oligonucleotides. These monomers have been used in the solid-phase synthesis of fluorogenic oligonucleotides for genetic analysis and the study of multi-stranded nucleic acid structures.

Graphical abstract: Synthesis of fluorophore and quencher monomers for use in Scorpion primers and nucleic acid structural probes

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Article information

DOI
https://doi.org/10.1039/B301859H
Article type
Paper
Submitted
19 Feb 2003
Accepted
07 May 2003
First published
28 May 2003

Org. Biomol. Chem., 2003,1, 2267-2275

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Synthesis of fluorophore and quencher monomers for use in Scorpion primers and nucleic acid structural probes

C. M. McKeen, L. J. Brown, J. T. G. Nicol, J. M. Mellor and T. Brown, Org. Biomol. Chem., 2003, 1, 2267 DOI: 10.1039/B301859H

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