Issue 19, 2003
From the journal:

Chemical Communications

Substitution of a bridgehead bromide by primary organolithium reagents†

Michael Harmata*a  and  Sumrit Wacharasindhua  

* Corresponding authors

a Department of Chemistry, University of Missouri-Columbia, Columbia, Missouri 65211
E-mail: harmatam@missouri.edu
Fax: 573-882-2754
Tel: 573-882-1097

Abstract

The reaction of ketone 1 with primary organolithium reagents in THF/HMPA affords not the expected carbonyl addition product but the product of bromide substitution, in reasonable yield.

Graphical abstract: Substitution of a bridgehead bromide by primary organolithium reagents

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Article information

DOI
https://doi.org/10.1039/B308112E
Article type
Communication
Submitted
17 Jul 2003
Accepted
07 Aug 2003
First published
20 Aug 2003

Chem. Commun., 2003, 2492-2493

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Substitution of a bridgehead bromide by primary organolithium reagents

M. Harmata and S. Wacharasindhu, Chem. Commun., 2003, 2492 DOI: 10.1039/B308112E

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