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Issue 15, 2002
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5-Propynyluracil·diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA

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Abstract

The Up·D base-pair (5-propynyl uracil·diaminopurine) is found to be more effective at non-enzymatic transcription than the corresponding natural T·A pair; under non-enzymatic reaction conditions where the natural T·A base-pair fails, a DNA template bearing Up efficiently directs the incorporation of D into a product RNA strand.

Graphical abstract: 5-Propynyluracil·diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA

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Publication details

The article was received on 10 May 2002, accepted on 10 Jun 2002 and first published on 20 Jun 2002


Article type: Communication
DOI: 10.1039/B204535D
Citation: Chem. Commun., 2002,0, 1568-1569
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    5-Propynyluracil·diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA

    J. C. Chaput, S. Sinha and C. Switzer, Chem. Commun., 2002, 0, 1568
    DOI: 10.1039/B204535D

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