Self-terminating, oxidative radical cyclizations of medium-sized cycloalkynones with inorganic and organic oxygen-centered radicals of type XO˙: the reaction pathway depends on the nature of X
Abstract
The reaction of various inorganic and organic oxygen-centered radicals of type XO˙ with cyclodec-5-ynone 6 can be used as a mechanistic probe to study the ease with which X˙ acts as a leaving group in self-terminating, oxidative radical cyclizations. It was observed that when X˙ has good leaving ability the reaction leads to formation of the bicyclic epoxy