Issue 20, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Transition metal complexes as linkers for solid phase synthesis: chromium carbonyl complexes as linkers for arenes

Alex C. Comely,ab   Susan E. Gibson (née Thomas),*ab   Neil J. Halesc  and  Mark A. Peplowb  

* Corresponding authors

a Department of Chemistry, King's College London, Strand, London, UK

b Department of Chemistry, Imperial College of Science, Technology and Medicine, South Kensington, London, UK

c AstraZeneca UK Ltd, Mereside, Alderley Park, Macclesfield, UK

Abstract

Substrates containing aromatic rings have been attached to ‘polymer supported triphenylphosphine’ using a chromium carbonyl linker, chemically manipulated, and released from the polymer to demonstrate the potential use of π-bound ligands in linker chemistry. Immobilisation of the phenylalanine derivative Fmoc-Phe-OtBu via its aromatic ring has been achieved and the resulting resin successfully subjected to standard amino acid deprotection and coupling procedures.

Graphical abstract: Transition metal complexes as linkers for solid phase synthesis: chromium carbonyl complexes as linkers for arenes

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Article information

DOI
https://doi.org/10.1039/B106582N
Article type
Paper
Submitted
23 Jul 2001
Accepted
10 Aug 2001
First published
01 Oct 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 2526-2531

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Transition metal complexes as linkers for solid phase synthesis: chromium carbonyl complexes as linkers for arenes

A. C. Comely, S. E. Gibson (née Thomas), N. J. Hales and M. A. Peplow, J. Chem. Soc., Perkin Trans. 1, 2001, 2526 DOI: 10.1039/B106582N

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