Issue 14, 2001

Diastereocontrolled Strecker reaction using (S)-5-phenylmorpholin-2-one

Abstract

Iminium ions derived from (S)-5-phenylmorpholin-2-one 1 undergo diastereoselective Strecker reactions using copper(I) cyanide and anhydrous hydrochloric acid; the major adducts may be degraded to D-α-amino acids.

Graphical abstract: Diastereocontrolled Strecker reaction using (S)-5-phenylmorpholin-2-one

Supplementary files

Article information

Article type
Communication
Submitted
09 May 2001
Accepted
01 Jun 2001
First published
27 Jun 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 1581-1583

Diastereocontrolled Strecker reaction using (S)-5-phenylmorpholin-2-one

L. M. Harwood, M. G. B. Drew, D. J. Hughes and R. J. Vickers, J. Chem. Soc., Perkin Trans. 1, 2001, 1581 DOI: 10.1039/B104052A

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