Issue 6, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Steroid-fullerene adducts from Diels–Alder reactions: characterization and the effect on the activity of Ca2+-ATPase

Lian-Sheng Li,a   Yun-Jin Hu,a   Yikang Wu,a   Yu-Lin Wu,*a   Jiachang Yueb  and  Fuyu Yang*b  

* Corresponding authors

a State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, China
E-mail: ylwu@pub.sioc.ac.cn

b National Laboratory of Biomacromolecules, Institute of Biophysics, Academia Sinica, 15 Datun Road, Beijing, China

Abstract

Two new fullerene steroids (1 and 6) have been prepared by the Diels–Alder reaction of silyloxydienes (2 and 3) with [60]fullerene, followed by hydrolysis of the silyl enol ether under acidic conditions. The isolation, characterization, UV-Vis and CD absorption studies of the adducts are presented. A preliminary study on the effect of 1 on sarcoplasmic reticulum (SR) Ca2+-ATPase and survival of human lung adenocarcinoma cancer A549 cells has also been carried out.

Graphical abstract: Steroid-fullerene adducts from Diels–Alder reactions: characterization and the effect on the activity of Ca2+-ATPase

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Article information

DOI
https://doi.org/10.1039/B007498P
Article type
Paper
Submitted
15 Sep 2000
Accepted
23 Jan 2001
First published
23 Feb 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 617-621

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Steroid-fullerene adducts from Diels–Alder reactions: characterization and the effect on the activity of Ca2+-ATPase

L. Li, Y. Hu, Y. Wu, Y. Wu, J. Yue and F. Yang, J. Chem. Soc., Perkin Trans. 1, 2001, 617 DOI: 10.1039/B007498P

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