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Issue 5, 2000
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Synthetic organoselenium compounds as antioxidants:glutathione peroxidase activity

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Organoselenium compounds find applications in organic synthesis, materials synthesis, ligand chemistry and biologically relevant processes. This review deals with the use of various synthetic organoselenium compounds as mimics of glutathione peroxidase (GPx), a selenoenzyme which catalyses the reduction of a variety of hydroperoxides and protects the cell membranes from oxidative damage. The mechanism by which these compounds catalyse the reduction of peroxides is also reviewed. The cyclic selenenamides and diselenides with suitably positioned substituents exert their catalytic activity by a mechanism similar to that of the natural enzyme.

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Publication details

The article was received on 28 Apr 2000 and first published on 31 Jul 2000

Article type: Review Article
DOI: 10.1039/A908114C
Chem. Soc. Rev., 2000,29, 347-357

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    Synthetic organoselenium compounds as antioxidants: glutathione peroxidase activity

    G. Mugesh and H. B. Singh, Chem. Soc. Rev., 2000, 29, 347
    DOI: 10.1039/A908114C

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