A Convenient One-pot Synthesis of Pyrimido[4,5-b]quinolines as 5-Deaza Non-classical Antifolate Inhibitors
Abstract
A convenient one-pot synthesis of pyrimido[4,5-b]quinolines as non-classical 5-deaza antifolate inhibitors by the reaction of 6-amino-4-oxo-2-thioxotetrahydropyrimidine 1 with aromatic aldehydes and dimedone is reported.