The enantioselective hydrogenation of a variety of α-keto acetals to the corresponding α-hydroxy acetals with Pt catalysts modified with cinchonidine derivatives is described with ees up to 97% and high reaction rates, and the influence of the substrate structure, the modifier and the reaction conditions (catalyst, solvent, temperature, pressure, modifier concentration) was investigated in some detail.
M. Studer, S. Burkhardt and H. Blaser, Chem. Commun., 1999, 1727 DOI: 10.1039/A905113I
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