Serinal-derived vinyl oxiranes as novel and versatile building blocks for the stereoselective synthesis of D- and L-erythro-sphingosines
Abstract
Oxazolidine vinyl oxirane 1, a novel and highly versatile building block for the preparation of enantiopure D-(+)-erythro-sphingosine and analogues, has been prepared by chloroallylboration of the Garner aldehyde with absolute stereocontrol and in good yield.