A trifunctional template 1 is synthesized from trans-4-hydroxy-L-proline and L-aspartic acid, immobilized on a solid-support, and used for the solid-phase synthesis of a cyclic conformationally restrained hexapeptide loop mimetic containing the motif Asn-Pro-Asn-Ala (NPNA); this is shown by NMR to populate a stable β-turn conformation in aqueous solution.
F. Emery, C. Bisang, M. Favre, L. Jiang and J. A. Robinson, Chem. Commun., 1996, 2155 DOI: 10.1039/CC9960002155
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