Synthesis of a chromogenic proline-containing glycopeptide
Abstract
A convenient synthesis of a chromogenic glycopeptide, O-(β-D-glucopyranosyl)-Ser-Pro-4-nitroanilide, involving the direct glycosylation of Fmoc-Ser-OH, coupling of L-proline-4-nitroanilide and sequential deprotection without diketopiperazine formation is reported.