Oxidation of methyl p-tolyl sulfide with bakers' yeast: preparation of a synthon of the mevinic acid-type hypocholestemic agents
Abstract
Bakers' yeast oxidized methyl p-tolyl sulfide to produce the R-sulfoxide 1 in good yield and high enantiomeric excess; the sulfoxide 1 was used to prepare (4R,6S)-tert-butyldimethylsilyloxy-6-hydroxymethyltetrahydropyran-2-one 15.