Lipase-catalysed reaction of (±)-4-alkyloxetan-2-ones 1a–c with benzyl alcohol gave (R)-1a(R = Me)(36%, 96% ee) and benzyl (S)-3-hydroxybutanoate 2a(51%, 85% ee), (R)-1b(R = Pr)(42%, 75% ee) and benzyl (S)-3-hydroxyhexanoate 2b(45%, 69% ee) and (S)-1c(R = Pri, 41%, 95% ee) and benzyl (R)-3-hydroxy-4-methylpentanoate 2c(43%, 90% ee), respectively.
Y. Koichi, K. Suginaka and Y. Yamamoto, J. Chem. Soc., Perkin Trans. 1, 1995, 1645 DOI: 10.1039/P19950001645
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