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Issue 11, 1994
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Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldehyde analogue

Abstract

(3R, 5R) Clavulanate-9-aldehyde 1 has been detected in Streptomyces clavuligerus and an NADPH dependent dehydrogenase capable of reducing 1 to clavulanic acid 2 has been isolated from this organism.

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Article information


J. Chem. Soc., Chem. Commun., 1994, 1281-1282
Article type
Paper

Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldehyde analogue

N. H. Nicholson, K. H. Baggaley, R. Cassels, M. Davison, S. W. Elson, M. Fulston, J. W. Tyler and S. R. Woroniecki, J. Chem. Soc., Chem. Commun., 1994, 1281
DOI: 10.1039/C39940001281

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