Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide; asymmetric synthesis of a C1–C8δ-lactone subunit
Abstract
The stereoselective, boron-mediated, aldol/reduction sequence, 4+5→8→9, allows an efficient asymmetric synthesis of the δ-lactone-containina. C1–C8 subunit 2 of discodermolide 1.