Substrate analogue studies on clavaminic acid synthase
Abstract
Incubation of N-α-acetyl-L-ornithine with clavaminic acid synthase led to the isolation of (E)-(2S)-5-amino-2-acetamidopent-3-enoic acid and (2S)-2-acetamido-5-amino-3-hydroxypentanoic acid, while incubation of N-α-acetyl-L-arginine led to the isolation of (2S)-2-acetamido-5-guanidino-3-hydroxypentanoic acid.