Evidence for an isocyanate formation in the alkaline hydrolysis of N1-alkyl derivatives of chlorpropamide, inhibitors of aldehyde dehydrogenase
Abstract
Trapping of a propyl isocyanate intermediate and entropies of activation data are consistent with an elimination–addition mechanism AxhDH+ DN(E1cB) for the hydrolysis of 1-alkyl-1-[(4-chlorophenyl)sulfonyl]-3-n-propylurea, the N1-alkyl derivatives of chlorpropamide, inhibitors of aldehyde dehydrogenase.