The first fully regiocontrolled total synthesis of the alkaloid colchicine 1 is described; the key step of the reaction sequence is the efficient biomimetic conversion of the σ-homo-o-benzoquinone monoacetal 11 into the α-tropolone-O-methyl ether 13.
M. G. Banwell, J. N. Lambert, M. F. Mackay and R. J. Greenwood, J. Chem. Soc., Chem. Commun., 1992, 974 DOI: 10.1039/C39920000974
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