Enantioselective construction of a quaternary stereogenic centre via tandem acid anhydride formation–intramolecular Michael reaction
Abstract
A novel method for the enantioselective construction of a quaternary stereogenic centre by tandem acid anhydride formation–intramolecular Michael reaction has been developed; a synthetic intermediate 16 for Hunteria and Aspidosperma indole alkaloids has been prepared by the application of this procedure.