Probing the interaction of Hoechst 33258 with an A–T rich oligonucleotide duplex using 1H NMR spectroscopy
Abstract
Changes in the 1H chemical shifts values for resonances of the decanucleotide duplex d(GGTAATTACC)2 provide an NMR ‘footprint’ of the interaction of the synthetic dye Hoechst 33258 with the DNA minor groove.