Efficient intramolecular general acid catalysis of vinyl ether hydrolysis by the neighbouring carboxylic acid group
Abstract
Intramolecular catalysis by the CO2H group of the hydrolysis of E-1-methoxy-2-(2-carboxyphenyl)ethylene 5, shows an effective molarity of almost 300 M, the highest measured for intramolecular proton transfer to carbon.