The intrinsic binding energy of an amide–hydroxy hydrogen bond [NHCO ⋯ HO] has been estimated (ca.– 12 kJ mol–1 at 293 K); the major contribution to this value appears to be entropic, hydrogen bond formation being driven by the release of ordered water from the carbonyl group.
J. P. L. Cox, I. A. Nicholls and D. H. Williams, J. Chem. Soc., Chem. Commun., 1991, 1295 DOI: 10.1039/C39910001295
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