Unusual formation of tetrahydro-1-isoquinolones from tetrahydroisoquinoline-1-carboxylic acids with carbodiimides and mechanistic aspects
Abstract
The reaction of tetrahydroisoquinoline-1-carboxylic acids with carbodiimides leads to the formation of tetrahydro-1-isoquinolones in high yields, involving a reaction between mesoionic 1,3-oxazol-5-one intermediates and molecular oxygen.