A new synthesis of methyl α-acetolactate based on thiazolium chemistry and modelled on the enzymatic synthesis of α-acetolactate catalysed by acetolactate synthase
Abstract
Methyl α-acetolactate [methyl 2-hydroxy-2-methyl-3-oxobutanoate (13)] has been synthesised via a series of adducts with benzothiazole in a manner analogous to the enzymatic reaction catalysed by acetolactate synthase.