Cytochalasan synthesis: an alternative approach to cytochalasin H
Abstract
The oxo ester (8), from the thiazolium salt catalysed conjugate addition of (S)-citronellal to ethyl acrylate, has been used in a synthesis of the cytochalasa-1,18,21-trione (3). This reacts both regio- and stereo-selectively with methylmagnesium chloride to provide the cytochalasin H precursor (4).