Possible effect of hydrogen bonding on methylation of pyrimidine and pyridone nucleosides
Abstract
Methylation of 1-(β-D-ribofuranosyl)-2-pyridone and -4-pyridone and 3-methyluridine with trimethylsulphonium hydroxide suggested that pyrimidine ribonucleosides (cytidine and uridine) differed in reactivity from the corresponding deoxyribonucleosides because of hydrogen bonding between the 2′-OH and C(2)O groups.