Non-enzymatic hydration, amine addition, and oxidation reactions of aza-arene oxides
Abstract
The 5,6- and 7,8-arene oxides of quinoline were found to undergo unusual addition reactions with water and primary amines at ambient tempreature to yield trans-dihydrodiol and trans-hydroxyamine adducts respectively; oxygen atom addition yielded N-oxide and trans-5,6,7,8-dioxide derivatives.