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Issue 16, 1989
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Cephalosporin C biosynthesis; stereochemistry of the incorporation of D,L,D-α-aminodipoyl-cysteinyl-(3S)-[2-2H,4-13C]valine into β-lactam compounds

Abstract

Incubation of D,L,D-α-Aminodipoyl-cysteinyl-(3S)-[2-2H,4-13C]valine (8b) with partially purified isopenicilln N synthetase fromCephalosporium acremonium CO 728 gave stereospecifically labelled (2R,3S)-[2′-13C,3-2H]penicillin N(9): further incubation of the product with partially purified deacetoxycephalosporin C/ deacetylcephalosporin C synthetase from C. acremonium CO 728 gave ring expanded products in which the 13C-label was incorporated exclusively into the C3′-exocyclic positions.

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Article information


J. Chem. Soc., Chem. Commun., 1989, 1141-1143
Article type
Paper

Cephalosporin C biosynthesis; stereochemistry of the incorporation of D,L,D-α-aminodipoyl-cysteinyl-(3S)-[2-2H,4-13C]valine into β-lactam compounds

J. E. Baldwin, R. M. Adlington, N. P. Crouch, N. J. Turner and C. J. Schofield, J. Chem. Soc., Chem. Commun., 1989, 1141
DOI: 10.1039/C39890001141

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