Issue 10, 1988

Peptide synthesis. Part 12. 3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl esters of fluorenylmethoxycarbonyl amino acids as self-indicating reagents for solid phase peptide synthesis

Abstract

The preparation and characterisation of 3,4-dihydro-4-oxo-1,2,3-benzotriazinyl esters (1) of Fmoc-amino acids and their use in solid phase peptide synthesis is described. Ionisation of the liberated hydroxy component (2) by the starting resin-bound amine provides a useful colour indicator of the progress of acylation reactions.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1988, 2887-2894

Peptide synthesis. Part 12. 3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl esters of fluorenylmethoxycarbonyl amino acids as self-indicating reagents for solid phase peptide synthesis

E. Atherton, J. L. Holder, M. Meldal, R. C. Sheppard and R. M. Valerio, J. Chem. Soc., Perkin Trans. 1, 1988, 2887 DOI: 10.1039/P19880002887

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