Human cholecystokinin (hCCK-33) has been synthesized by selective esterification of the Tyr-phenolic OH group (position 27) of unsulphated hCCK-33 with pyridine–SO3 complex after reversible masking of other functional groups by hard base (F–)-labile protecting groups: amino functions by the fluoren-9-ylmethoxycarbonyl group and the Ser-OH group by the t-butyldiphenylsilyl group.
N. Fujii, S. Futaki, H. Morimoto, K. Inoue, R. Doi, T. Tobe and H. Yajima, J. Chem. Soc., Chem. Commun., 1988, 324 DOI: 10.1039/C39880000324
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