A new method is reported for the conversion of azido acids into lactams, via thioester formation and in situ azide reduction and cyclisation under high-dilution conditions; since the quantitative conversion of macrolactams to macrolactones has been shown to be feasible, this results in an indirect, alternative macrolactonisation procedure.
M. Bartra, V. Bou, J. Garcia, F. Urpi and J. Vilarrasa, J. Chem. Soc., Chem. Commun., 1988, 270 DOI: 10.1039/C39880000270
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